Cleft Palate Produced in Mice by Human-Equivalent Dosage with Triamcinolone.
نویسنده
چکیده
Triamcinolone produced cleft palates in mouse embryos at a dosage proportionate, by body weight, to common therapeutic dosage for humans. Thus, it showed much greater teratogenicity than other glucocorticoids tested on mice. Widely ranging doses of desoxycorticosterone did not produce cleft palates.
منابع مشابه
Cleft palate induction in hamster fetuses by glucocorticoid hormones and their synthetic analogues.
The effect of prenatal administration of different doses of cortisone, corticosterone, dexamethasone, triamcinolone and prednisolone on the fetus and its palatal development was studied. All the glucocorticoids, except cortisone, produced cleft palate in the fetuses. Both the total frequency and morphologically different types of cleft palate were related to the dose of the teratogen. Triamcino...
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ورودعنوان ژورنال:
- Science
دوره 149 3686 شماره
صفحات -
تاریخ انتشار 1965